Such over-the-counter analgesics as aspirin, acetaminophen, ibuprofen, and naproxen sodium present no danger for most people when taken at the recommended dosage. Some conditions, however, make taking even these common painkillers dangerous for the kidneys. Also, taking one or a combination of these drugs regularly, over a long period of time, may increase the risk for kidney problems.
There have been incidences of acute kidney failure attributed to the use of such painkillers as aspirin, ibuprofen, and naproxen among patients with risk factors such as systemic lupus erythematosus, advanced age, chronic kidney conditions, or a recent binge of alcohol consumption. Acute kidney failure requires emergency dialysis to clean the blood, after which normal kidney function usually returns.
Patients with conditions that put them at risk for acute kidney failure should check with their physicians before taking any medicine.